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b16 b cpap cal 62 hela mcf 7 skbr 3 tc 1 a549  (ATCC)


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    ATCC b16 b cpap cal 62 hela mcf 7 skbr 3 tc 1 a549
    B16 B Cpap Cal 62 Hela Mcf 7 Skbr 3 Tc 1 A549, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 10512 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hela+1+3/U-87+MG/pm41892485-74-203-242
    Average 99 stars, based on 10512 article reviews
    b16 b cpap cal 62 hela mcf 7 skbr 3 tc 1 a549 - by Bioz Stars, 2026-09
    99/100 stars

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    Recombinant:

    Article Title: TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Mouse monoclonal anti-TERF2 Novus Cat#NB100-56506; RRID: AB_839054 Rabbit polyclonal anti-TERF2 Novus Cat#NB110-57130; RRID: AB_844199 Rabbit polyclonal anti-TERF2IP Novus Cat#NB100-292; RRID: AB_10000825 Rabbit polyclonal anti-TPP1 Bethyl Cat#A303-069A; RRID: AB_10890369 Rabbit polyclonal anti-POT1 Proteintech Cat#10581-1-AP; RRID: AB_2284057 Rabbit anti-TERF1 Jan Karlseder N/A Mouse monoclonal anti-FLAG (HRP) Sigma-Aldrich Cat#A8592; RRID: AB_439702 Rabbit polyclonal anti-53BP1 Novus Cat#NB100-304; RRID: AB_10003037 Goat polyclonal anti-rabbit (Cy3) Invitrogen Cat#A10520; RRID: AB_10563288 Goat polyclonal anti-rabbit (HRP) Invitrogen Cat#31460; RRID: AB_228341 Goat polyclonal anti-mouse (HRP) Invitrogen Cat#31439; RRID: AB_228292 Bacterial and virus strains One Shot BL21(DE3) Chemically Competent E. coli Invitrogen Cat#C600003 TOP10 Chemically Competent E. coli Invitrogen Cat#C404006 Chemicals, peptides, and recombinant proteins TEV protease New England Biolabs Cat#P8112 Lipofectamine 2000 Invitrogen Cat#11668500 HaloPROTAC-E AOBIOUS Inc. Cat#AOB13155 Ouabain Sigma-Aldrich Cat#O3125 Thymidine Sigma-Aldrich Cat#T1895 PNA TelC-Alexa488 PNA Bio Cat#F1004 Janelia Fluor JFX650 HaloTag Ligand Grimm et al. 78 ; Promega Cat#HT1070 Janelia Fluor 657 HaloTag Ligand Grimm et al. 79 N/A Janelia Fluor 549 HaloTag Ligand Grimm et al. 80 ; Promega Cat#HT1020 Hoechst 33342 Thermo Scientific Cat#62249 Prolong Diamond Antifade Mountant Invitrogen Cat#P36970 Super Nuclease Sino Biological Cat#SSNP01 ANTI-FLAG M2 Affinity Gel Millipore Cat#A2220 3xFLAG Peptide Sigma-Aldrich Cat#F4799 Ni Sepharose 6 Fast Flow histidine-tagged protein purification resin Cytiva Cat#17531801 Critical commercial assays FxCycle PI/RNase Staining Solution Invitrogen Cat#F10797 SuperSignal West Femto Maximum Sensitivity Substrate Thermo Scientific Cat#34094 4–15% Mini-PROTEAN TGX Stain-Free Protein Gels Bio-Rad Cat#4568083 4–15% Criterion TGX Stain-Free Protein Gel Bio-Rad Cat#5678084 Trans-Blot Turbo RTA Mini 0.2 μm Nitrocellulose Transfer Kit Bio-Rad Cat#1704270 Deposited data All generated plasmids will be deposited at Addgene N/A (Continued on next page) 16 Cell Reports 44, 116178, September 23, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Photobleaching and residence time analysis algorithms This study https://github.com/SchmidtLabMSU/ ShelterinAnalysis Experimental models: Cell lines Human: HeLa EM2-11ht Weidenfeld et al. 50 RRID: CVCL_WN71 Human: HeLa EM2-11ht, FLAG-HaloTag-TRF1 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TRF2 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TIN2 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-POT1 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TRF2, RAP1-KO This study N/A Human: HeLa 1.3 Takai et al. 48 RRID: CVCL_B5DA Human: HeLa 1.3, FLAG-HaloTag-TRF2 This study N/A Human: HeLa 1.3, FLAG-HaloTag-TIN2 This study N/A Human: U2OS ATCC Cat#HTB-96; RRID: CVCL_0042 Human: U2OS, FLAG-HaloTag-TRF1 This study N/A Human: U2OS, FLAG-HaloTag-TRF2 This study N/A Human: U2OS, FLAG-HaloTag-TIN2 This study N/A Human: U2OS, FLAG-HaloTag-TPP1 This study N/A Human: U2OS, FLAG-HaloTag-POT1 This study N/A Human: U2OS, FLAG-HaloTag-RAP1 This study N/A Human: U2OS, FLAG-HaloTag-TRF2, RAP1-KO This study N/A Oligonucleotides All oligonucleotides used in this study can be found in Table S2 This study N/A Recombinant DNA pRK2-mNeonGreen-TRF1 plasmid This study N/A pRK2-mNeonGreen-TRF2 plasmid This study N/A pRK2-mNeonGreen-TIN2 plasmid This study N/A pRK2-mNeonGreen-POT1 plasmid This study N/A pFastBacDual plasmid Gibco Cat#10360014 pFastBacDual-FLAG-HaloTag-TRF1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TRF2 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TIN2 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TPP1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-POT1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-RAP1 HRD plasmid This study N/A pX330-U6-Chimeric_BB-CBh-hSpCas9 plasmid Cong et al. 81 Addgene plasmid #42230 pX330-TRF1 plasmid This study N/A pX330-TRF2 plasmid This study N/A (Continued on next page) Cell Reports 44, 116178, September 23, 2025 17 ..

    Plasmid Preparation:

    Article Title: TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Mouse monoclonal anti-TERF2 Novus Cat#NB100-56506; RRID: AB_839054 Rabbit polyclonal anti-TERF2 Novus Cat#NB110-57130; RRID: AB_844199 Rabbit polyclonal anti-TERF2IP Novus Cat#NB100-292; RRID: AB_10000825 Rabbit polyclonal anti-TPP1 Bethyl Cat#A303-069A; RRID: AB_10890369 Rabbit polyclonal anti-POT1 Proteintech Cat#10581-1-AP; RRID: AB_2284057 Rabbit anti-TERF1 Jan Karlseder N/A Mouse monoclonal anti-FLAG (HRP) Sigma-Aldrich Cat#A8592; RRID: AB_439702 Rabbit polyclonal anti-53BP1 Novus Cat#NB100-304; RRID: AB_10003037 Goat polyclonal anti-rabbit (Cy3) Invitrogen Cat#A10520; RRID: AB_10563288 Goat polyclonal anti-rabbit (HRP) Invitrogen Cat#31460; RRID: AB_228341 Goat polyclonal anti-mouse (HRP) Invitrogen Cat#31439; RRID: AB_228292 Bacterial and virus strains One Shot BL21(DE3) Chemically Competent E. coli Invitrogen Cat#C600003 TOP10 Chemically Competent E. coli Invitrogen Cat#C404006 Chemicals, peptides, and recombinant proteins TEV protease New England Biolabs Cat#P8112 Lipofectamine 2000 Invitrogen Cat#11668500 HaloPROTAC-E AOBIOUS Inc. Cat#AOB13155 Ouabain Sigma-Aldrich Cat#O3125 Thymidine Sigma-Aldrich Cat#T1895 PNA TelC-Alexa488 PNA Bio Cat#F1004 Janelia Fluor JFX650 HaloTag Ligand Grimm et al. 78 ; Promega Cat#HT1070 Janelia Fluor 657 HaloTag Ligand Grimm et al. 79 N/A Janelia Fluor 549 HaloTag Ligand Grimm et al. 80 ; Promega Cat#HT1020 Hoechst 33342 Thermo Scientific Cat#62249 Prolong Diamond Antifade Mountant Invitrogen Cat#P36970 Super Nuclease Sino Biological Cat#SSNP01 ANTI-FLAG M2 Affinity Gel Millipore Cat#A2220 3xFLAG Peptide Sigma-Aldrich Cat#F4799 Ni Sepharose 6 Fast Flow histidine-tagged protein purification resin Cytiva Cat#17531801 Critical commercial assays FxCycle PI/RNase Staining Solution Invitrogen Cat#F10797 SuperSignal West Femto Maximum Sensitivity Substrate Thermo Scientific Cat#34094 4–15% Mini-PROTEAN TGX Stain-Free Protein Gels Bio-Rad Cat#4568083 4–15% Criterion TGX Stain-Free Protein Gel Bio-Rad Cat#5678084 Trans-Blot Turbo RTA Mini 0.2 μm Nitrocellulose Transfer Kit Bio-Rad Cat#1704270 Deposited data All generated plasmids will be deposited at Addgene N/A (Continued on next page) 16 Cell Reports 44, 116178, September 23, 2025 .. REAGENT or RESOURCE SOURCE IDENTIFIER Photobleaching and residence time analysis algorithms This study https://github.com/SchmidtLabMSU/ ShelterinAnalysis Experimental models: Cell lines Human: HeLa EM2-11ht Weidenfeld et al. 50 RRID: CVCL_WN71 Human: HeLa EM2-11ht, FLAG-HaloTag-TRF1 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TRF2 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TIN2 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-POT1 This study N/A Human: HeLa EM2-11ht, FLAG-HaloTag-TRF2, RAP1-KO This study N/A Human: HeLa 1.3 Takai et al. 48 RRID: CVCL_B5DA Human: HeLa 1.3, FLAG-HaloTag-TRF2 This study N/A Human: HeLa 1.3, FLAG-HaloTag-TIN2 This study N/A Human: U2OS ATCC Cat#HTB-96; RRID: CVCL_0042 Human: U2OS, FLAG-HaloTag-TRF1 This study N/A Human: U2OS, FLAG-HaloTag-TRF2 This study N/A Human: U2OS, FLAG-HaloTag-TIN2 This study N/A Human: U2OS, FLAG-HaloTag-TPP1 This study N/A Human: U2OS, FLAG-HaloTag-POT1 This study N/A Human: U2OS, FLAG-HaloTag-RAP1 This study N/A Human: U2OS, FLAG-HaloTag-TRF2, RAP1-KO This study N/A Oligonucleotides All oligonucleotides used in this study can be found in Table S2 This study N/A Recombinant DNA pRK2-mNeonGreen-TRF1 plasmid This study N/A pRK2-mNeonGreen-TRF2 plasmid This study N/A pRK2-mNeonGreen-TIN2 plasmid This study N/A pRK2-mNeonGreen-POT1 plasmid This study N/A pFastBacDual plasmid Gibco Cat#10360014 pFastBacDual-FLAG-HaloTag-TRF1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TRF2 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TIN2 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-TPP1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-POT1 HRD plasmid This study N/A pFastBacDual-FLAG-HaloTag-RAP1 HRD plasmid This study N/A pX330-U6-Chimeric_BB-CBh-hSpCas9 plasmid Cong et al. 81 Addgene plasmid #42230 pX330-TRF1 plasmid This study N/A pX330-TRF2 plasmid This study N/A (Continued on next page) Cell Reports 44, 116178, September 23, 2025 17 ..

    Cell Culture:

    Article Title: A Near-Infrared Fluorogenic Pyrrole–Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres
    Article Snippet: ・Cell culture U2OS cells (ATCC) were cultured in McCoy’s 5A (Modified) medium (Thermo Fisher Scientific) containing 10% fetal bovine serum (FBS) (Sigma-Aldrich) at 37 °C under 5% CO2 and humidified atmosphere. .. A549 (JCRB Cell Bank), HeLa S3 (ATCC) and HeLa 1.3 (a generous gift from Dr. T. de Lange) were cultured in Dulbecco’s Modified Eagle Medium (Thermo Fisher Scientific) containing 10% FBS at the same condition. .. For the experiments, cells were seeded in 96 well plate (Greier Bio-One) (for WST assay), μ-Slide 8 well dishes (ibidi) (for imaging in A549 cells and time-lapse imaging of mitosis in U2OS cells) or 4 well glass bottom dishes (Matsunami) (for the other experiments) 1 day or 2 days (for endocytosis suppression) before the chemical treatments.

    Modification:

    Article Title: A Near-Infrared Fluorogenic Pyrrole–Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres
    Article Snippet: ・Cell culture U2OS cells (ATCC) were cultured in McCoy’s 5A (Modified) medium (Thermo Fisher Scientific) containing 10% fetal bovine serum (FBS) (Sigma-Aldrich) at 37 °C under 5% CO2 and humidified atmosphere. .. A549 (JCRB Cell Bank), HeLa S3 (ATCC) and HeLa 1.3 (a generous gift from Dr. T. de Lange) were cultured in Dulbecco’s Modified Eagle Medium (Thermo Fisher Scientific) containing 10% FBS at the same condition. .. For the experiments, cells were seeded in 96 well plate (Greier Bio-One) (for WST assay), μ-Slide 8 well dishes (ibidi) (for imaging in A549 cells and time-lapse imaging of mitosis in U2OS cells) or 4 well glass bottom dishes (Matsunami) (for the other experiments) 1 day or 2 days (for endocytosis suppression) before the chemical treatments.



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    Heatmap of ADC payload activity across multidrug-resistant and control cell lines. (A) P-gp efflux potential: Unsupervised clustering of AUC values from dose-response viability assays of a panel of cytotoxic agents tested against parental, multidrug-resistant, and genetically modified KB and MDR-19 cell lines. Cell lines include KB-3-1 (parental) and KB-8-5-11 (P-gp overexpressing); HEK-293-derived MDR-19 ( ABCB1 transfected) and its vector control (pcDNA), as well as P-gp–inhibited counterparts (+TQR, tariquidar); (B) ABCG2 efflux potential: Unsupervised clustering of AUC values from dose-response viability assays of a panel of cytotoxic agents tested against parental, genetically modified, and multidrug-resistant HEK and H460 cell lines. Cell lines include H460 (parental) and H460-MX20 (ABCG2 overexpressing); HEK-derived HEK-R5 (ABCG2 transfected) and its vector control (pcDNA), as well as ABCG2–inhibited counterparts (+Ko143). ADC: Antibody-drug conjugate; P-gp: P-glycoprotein; AUC: area under the curve; ABCB1: adenosine triphosphate-binding cassette B1; TQR: tariquidar; MOA: mechanism of action.

    Journal: Cancer Drug Resistance

    Article Title: Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters

    doi: 10.20517/cdr.2025.151

    Figure Lengend Snippet: Heatmap of ADC payload activity across multidrug-resistant and control cell lines. (A) P-gp efflux potential: Unsupervised clustering of AUC values from dose-response viability assays of a panel of cytotoxic agents tested against parental, multidrug-resistant, and genetically modified KB and MDR-19 cell lines. Cell lines include KB-3-1 (parental) and KB-8-5-11 (P-gp overexpressing); HEK-293-derived MDR-19 ( ABCB1 transfected) and its vector control (pcDNA), as well as P-gp–inhibited counterparts (+TQR, tariquidar); (B) ABCG2 efflux potential: Unsupervised clustering of AUC values from dose-response viability assays of a panel of cytotoxic agents tested against parental, genetically modified, and multidrug-resistant HEK and H460 cell lines. Cell lines include H460 (parental) and H460-MX20 (ABCG2 overexpressing); HEK-derived HEK-R5 (ABCG2 transfected) and its vector control (pcDNA), as well as ABCG2–inhibited counterparts (+Ko143). ADC: Antibody-drug conjugate; P-gp: P-glycoprotein; AUC: area under the curve; ABCB1: adenosine triphosphate-binding cassette B1; TQR: tariquidar; MOA: mechanism of action.

    Article Snippet: The HeLa derivative KB-3-1 was purchased from ATCC and the P-gp overexpressing KB-8-5-11 subline was generated by selection with 100 ng/mL colchicine.

    Techniques: Activity Assay, Control, Genetically Modified, Derivative Assay, Transfection, Plasmid Preparation, Binding Assay

    P-gp overexpression confers resistance to treatment with MIRV. Three-day cytotoxicity assays were performed with MIRV as described in the Materials and Methods using the OVCAR8/NCI-ADR-RES pair (left) or the KB 3-1/KB 8-5-11 pair (right). Results from one of two independent experiments are shown. P-gp: P-glycoprotein; MIRV: mirvetuximab soravtansine.

    Journal: Cancer Drug Resistance

    Article Title: Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters

    doi: 10.20517/cdr.2025.151

    Figure Lengend Snippet: P-gp overexpression confers resistance to treatment with MIRV. Three-day cytotoxicity assays were performed with MIRV as described in the Materials and Methods using the OVCAR8/NCI-ADR-RES pair (left) or the KB 3-1/KB 8-5-11 pair (right). Results from one of two independent experiments are shown. P-gp: P-glycoprotein; MIRV: mirvetuximab soravtansine.

    Article Snippet: The HeLa derivative KB-3-1 was purchased from ATCC and the P-gp overexpressing KB-8-5-11 subline was generated by selection with 100 ng/mL colchicine.

    Techniques: Over Expression